Is Nugenix Total T Safe? (We Analyzed The Ingredients)

Among testosterone-boosting dietary supplements, Nugenix Total T is gaining popularity for its suggested health benefits. 

Increasing testosterone production is desired by many, as age and other factors can influence the amount of testosterone produced by both men and women. 

However, testosterone is a tightly regulated hormone with multiple downstream effects if produced in excess quantities. 

Additionally, some testosterone boosters contain ingredients that can be labeled as hormone disruptors (or may simply have an unknown influence on the body!). 

So, we wanted to get to the bottom of the safety claims associated with Nugenix Total T to ensure that its consumers know all of the risks and benefits associated with the supplement. 

We’ll provide an overview of Nugenix Total T, investigate each ingredient, and offer guidance on the next steps. Let’s begin!

Overview of Nugenix Total T

Nugenix testosterone booster

Testosterone boosters have been popularized in a number of demographics as a way to combat symptoms of low testosterone or hypogonadism. 

Hypogonadism can cause fatigue, mood changes, a decrease in muscle mass, a decrease in bone density, low libido, and more. 

However, in a small number of individuals, testosterone boosters can address and even reduce these symptoms significantly! 

Individuals who regularly use Nugenix Total T report an increase in their overall energy and improvements in sexual health. 

Claims directly from the supplement say that it is intended to increase lean muscle mass, boost testosterone, and increase libido. This product is marketed toward men over 40, as testosterone decreases steeply as men age. 

Therefore, to see if Nugenix Total T is a viable option for testosterone boosting, we will analyze its ingredients to determine if it is safe or not. However, it is important to always consult with a physician before choosing to take Nugenix Total T. 

Ingredients Analysis

Nugenix T ingredients

Now, let’s dive into the ingredient list for Nugenix Total T!

These ingredients, although not considered to be pharmaceutical in nature, can still have the same effect as a traditional medication. 

Additionally, some interactions of these vitamins, minerals, extracts, and other ingredients may not be fully understood.

Finally, it is wise to have bloodwork done to check individual levels of each ingredient in this list – especially the vitamins. 

Vitamin D (Cholecalciferol)

If you’ve been outside today, you’ve probably made some vitamin D!

Vitamin D is a fat-soluble vitamin, which means that it stays in the body for longer than a water-soluble vitamin, like vitamin C. 

Vitamin D is largely used to improve or maintain bone health, although there may be additional health benefits of this vitamin. 

Since low testosterone is known to progress bone demineralization, vitamin D can slow this process down!

Vitamin B6 (Pyridoxine Hydrochloride)

Vitamin B6 performs a range of functions in the body, such as energy production, brain maintenance, immune support, and more. 

In terms of testosterone production, vitamin B6 acts as a partner for enzymes that make steroid hormones – increasing testosterone sensitivity. 

However, B vitamins are the subject of some controversy in the media, as some are concerned about potential genetic variants that can slow the breakdown of vitamin B. So, always consult with your doctor if you have a B vitamin gene variant!  

Vitamin B12 (Methylcobalamin) 

Vitamin B12 also performs some critical tasks in the body, such as red blood cell formation, DNA maintenance, and energy production.

Unfortunately, there is no substantial evidence to support vitamin B12’s role in testosterone production. 

However, B12 supplementation can increase energy levels and workout satisfaction, so it can mimic the effects of increased testosterone in some individuals. 

Additionally, both B vitamins mentioned in this article can be overdosed on, so make sure you’re taking the recommended amount. 


Moving on from vitamins, zinc is an important mineral that facilitates testosterone production.

Particularly, zinc tells luteinizing hormone to be secreted, which then informs the male sex organs to begin producing testosterone. Interestingly, some evidence suggests a link between zinc deficiency and low testosterone in males. 

Fenugreek Extract

Fenugreek extract is a plant-derived extract that is often found in traditional medicine. 

Fenugreek contains a number of healthy compounds, such as alkaloids and flavonoids. 

For its potential testosterone benefits, the correlation between fenugreek ingestion and testosterone production has only shown mild results. 

L-Citrulline Malate

L-citrulline malate is an amino acid that is involved with the removal of ammonia from the body. This amino acid is useful for people who exercise, as it can improve athletic performance and cardiovascular health. 

However, there is not enough evidence to suggest that L-citrulline malate is impactful to bodily testosterone production. 

Epimedium Sagittatum Extract

As an herb often used in traditional Chinese medicine, epimedium sagittatum extract is primarily used for increasing sexual function and libido. 

Despite the handful of studies that conclude that epimedium sagittatum extract inspires sex drive, it has not been meaningfully linked to testosterone boosting. 

Nettle Root Extract

Another natural medicine compound is found in nettle root extract. This extract is commonly used to improve prostate function, which is intimately related to testosterone production and release.

Moreover, nettle root extract can interact with globulin (protein), which allows for a greater testosterone release overall. 

Maca Root Extract

Native to the Andes Mountains, maca is a common aphrodisiac used to treat low libido, although it is not a proven method. 

Maca root is high in vitamin C, iron, and copper, while also containing glucosinolates. Glucosinolates have anti-tumor properties and support antioxidants. 

However, maca root’s impact on sexual function does not indicate a link to testosterone production. 

Eurycoma Longifolia Extract

Eurycoma longifolia extract has a potential influence on testosterone, but research remains ongoing. 

This extract may work by stimulating Leydig cells in the testes (male sex organ), thereby promoting testosterone production and release. 

Additionally, there have been small studies linking eurycoma longifolia to cortisol, the body’s stress hormone. 

Mucuna Pruriens Extract

Mucuna Pruriens extract is a fascinating one – this extract contains the precursor compound for the neurotransmitter dopamine or L-DOPA

Interestingly, L-DOPA is often used to treat Parkinson’s disease, as it influences greater dopamine release in the brain. 

This extract was added based on reports of users finding improvements in their libido and mood, but it is unclear whether this is a significant enough effect. 


So, is Nugenix Total T safe? In certain circumstances, this supplement may benefit users; however, the unregulated supplement market makes consumption come with some risks. 

The ingredients present in Nugenix Total T can be incorporated into a healthy diet, but vitamin overdose can occur if the user does not know their baseline levels. 

Many of the ingredients in Nugenix Total T mimic the effects of increased testosterone while having no real effect on hormonal production. 

Moreover, the Food and Drug Administration (FDA) in the United States does not regulate or condone the use of testosterone-boosting supplements in place of traditional hormone therapy! 

However, anecdotal evidence suggests that testosterone-boosting supplements like Nugenix Total T may be worth trying, as long as a doctor is consulted first.